Stroke Recovery and Rehabilitation Roundtable - development, monitoring and reporting - Marion Walker

July 20, 2017

Improving the development, monitoring and reporting of stroke rehabilitation research: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable (SRRR) 

An international partnership of stroke rehabilitation experts committed to developing consensus-based core recommendations with a remit of addressing the issues identified as limiting stroke rehabilitation research in the areas of developing, monitoring and reporting stroke rehabilitation interventions. Work exploring each of the three areas took place via multiple teleconferences and a two-day meeting in Philadelphia in May 2016 15    recommendations were made under the auspice of the Stroke Recovery and Rehabilitation Roundtable taskforce! 

Recent reviews demonstrate that the quality of stroke rehabilitation research has continued to improve over the last four decades, however, despite this progress there are still so many barriers to moving the field forward. Rigorous development, monitoring and complete reporting of interventions in stroke trials are essential in providing rehabilitation evidence that is robust, meaningful and implementable. 

To validate the need for the 15 recommendations the #SRRR group reviewed all stroke rehabilitation trials published in 2015 (n=182 papers) and found that highlighted was that the majority of publications didn’t clearly describe how interventions were developed or monitored during the trial. In particular, under-reporting of the theoretical rationale for the intervention and the components of the intervention calls into question many interventions that have been evaluated for efficacy. 

More trials were found to have addressed the reporting of interventions recommendations than those related to development or monitoring. Nonetheless the majority of reporting recommendations were still not adequately described. 

To progress the field of stroke rehabilitation research and to ensure stroke patients receive optimal evidence based clinical care we urge the research community to endorse and adopt our recommendations. 

I’m Carmen Lahiff-Jenkins and I spoke to Professor Marion Walker who took me through the recommendations and the thinking behind their development.  

Please clink this link to go to the landing page for the series

 

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Stroke Recovery and Rehabilitation Roundtable - definitions - Karen Borschmann and Kate Hayward

July 19, 2017

Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce. 

Common language and definitions were required to develop an agreed framework spanning the four working groups for the The Stroke Recovery and Rehabilitation Roundtable taskforce: translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. 

The Stroke Recovery and Rehabilitation Roundtable (SRRR) was convened with the aim to move rehabilitation research forward. Working collectively across four initial priority areas the #SRRR team reviewed, discussed, and attempted to achieve consensus on key recommendations in each of the areas of translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. 

I’m Carmen Lahiff-Jenkins, Managing Editor of the International journal of Stroke and I spoke to Karen Borschmann and Kate Hayward researchers involved in the SRRR project. 

Click or tap here to go straight into the series free online

The music for this podcast was 'Kool Kats' by Kevin MacLeod 

 

 

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Stroke Recovery and Rehabilitation Roundtable - Translational/Preclinical with Dr Dale Corbett

July 6, 2017

Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. We know that moving preclinical treatments into the clinical realm has been fraught with notorious difficulties, one very well known area has been, of course the incredible disappointments with neuroprotection. In comparison stroke recovery involves distinct biological principles and a very different time window, it is in fact unlike acute stroke at all!

 

We spoke to Dr Dale Corbett Proferssor in Cellular and mollecular medicine in the faculty of Medicine at the Univeristy of Ottawa, who was the lead author on the Stroke Rrecovery and Rehabilitation Roundtable paper on Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline.

 

The music used in this podcast is 'Kool Kats' by Kevin MacLeod

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Stroke Recovery and Rehabilitation Roundtable - Biomarkers with Dr Lara Boyd

July 5, 2017

A biological marker or biomarker is a naturally occurring molecule, gene, or characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention

Dr Lara Boyd, Physical therapist from the University of British Columbia, Canada. 

@laboyd47; @UBC_BrainLab

The music for this podcast was 'Kool Kats' by Kevin MacLeod 

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Long-term cost-effectiveness of thrombectomy for acute ischaemic stroke in real life: An analysis based on data from the Swedish Stroke Register (Riksstroke)

April 9, 2017

Thrombectomy has a small effect on hospital costs except for the direct intervention cost. However, thrombectomy is highly likely to lead to substantial cost savings in the social service sector.

My name is Carmen Lahiff-Jenkins and I’m the Managing Editor of the International Journal of Stroke and I spoke to Katarina Steen Carlsson, PhD in Economics, from the Department of Clinical Sciences, Malmö, Health Economics, Lund University, Sweden who with a team of researchers from Lund investigated the long-term cost-effectiveness of thrombectomy after thrombolysis versus thrombolysis alone using real-world outcome data on need for health care, home help and nursing home care.

This research has been published online in the International Journal of Stroke in the article Long-term cost-effectiveness of thrombectomy for acute ischaemic stroke in real life: An analysis based on data from the Swedish Stroke Register (Riksstroke)

The international Journal of Stroke is the flagship publication of the World Stroke Organisation, please consider becoming a member.

Download article from here

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Thrombectomy accessibility after transfer from a primary stroke center: analysis of a 3-year prospective registry

April 9, 2017

No comprehensive study exists on Mechanical Thrombectomy accessibility for patients admitted to a primary stroke center without on-site interventional neuroradiology services.

My name is Carmen Lahiff-Jenkins and I’m the Managing Editor of the International Journal of Stroke and I spoke to Dr Denis Sablot from the Centre Hospitalier de Perpignan, Neurologie, France and submitting author of Thrombectomy accessibility after transfer from a primary stroke center: analysis of a 3-year prospective registry, this article is available online at the International Journal of Stroke website, hosted by SAGE.  

This podcast recordng was developed and produced by the World Stroke Organization.

Download article here. 

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Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial) - Rationale and study design Tobias Geisler

February 12, 2017

 

 Article link here

Optimal secondary prevention of embolic stroke of undetermined source (ESUS) is not established. The current standard in these patients is acetylsalicylic acid (ASA), despite high prevalence of yet undetected paroxysmal atrial fibrillation (AF).

ESUS is caused by embolic disease and associated with a high risk of recurrent ischemic strokes and clinically silent cerebral ischemic lesions. The ATTICUS randomized trial will investigate the impact of AF detected by ICM and the effects of early anticoagulation with apixaban compared to antiplatelet therapy with ASA on the incidence of NIL after ESUS.

I’m Carmen Lahiff-Jenkins Managing Editor of the International Journal of Stroke and I spoke to Tobias Geisler, lead author for the Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial) - Rationale and study design published in the International Journal of Stroke. 

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Impact of stroke education on middle school students and their parents: a cluster randomized trial a chat with João Pedro Marto

February 12, 2017

Impact of stroke education on middle school students and their parents: a cluster randomized trial a chat with João Pedro Marto

School students are an attractive target for stroke education due to the potential impact on stroke prevention and recognition. Additionally, these students can drive behavioral changes in their families. This trial, the results published in the International Journal of Stroke, found that school-based interventions might improve stroke knowledge in middle school students and their parents. I’m Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke and I spoke to lead author João Pedro Marto.

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Global Stroke Statistics

November 27, 2016

The Global Stroke Statistics paper is up to date data on incidence, mortality, and case-fatality for stroke are important for setting the agenda for prevention and healthcare. Carmen Lahiff-Jenkins, Managing Editor of the International Journal of Stroke spoke to Tharshanah Thayabaranathan. 

http://wso.sagepub.com/content/early/2016/10/27/1747493016676285.abstract

 

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Cheryl Carcel - Stroke Society Australasia

September 26, 2016
Paid work is an important marker to stroke recovery, I’m Carmen Lahiff-Jenkins and I spoke to Cheryl Carcel clinical research fellow and research coordinator at The George Institute for Global Health.
Cheryl Carcel's substudy, of the POISE study looked at unpaid and paid work after 12 months after stroke, she presented her data at the Stroke Society Australasia meeting in Brisbane. 
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